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Registros recuperados: 14
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Adeno-associated virus for cystic fibrosis gene therapy BJMBR
Martini,S.V.; Rocco,P.R.M.; Morales,M.M..
Gene therapy is an alternative treatment for genetic lung disease, especially monogenic disorders such as cystic fibrosis. Cystic fibrosis is a severe autosomal recessive disease affecting one in 2500 live births in the white population, caused by mutation of the cystic fibrosis transmembrane conductance regulator (CFTR). The disease is classically characterized by pancreatic enzyme insufficiency, an increased concentration of chloride in sweat, and varying severity of chronic obstructive lung disease. Currently, the greatest challenge for gene therapy is finding an ideal vector to deliver the transgene (CFTR) to the affected organ (lung). Adeno-associated virus is the most promising viral vector system for the treatment of respiratory disease because it...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Gene therapy; Adeno-associated virus; Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator; Vectors.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001100004
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Blood sucking Diptera (Culicidae, Psychodidae, Simuliidae) in forest fragment under impact of dam in the borderland of Rio Grande do Sul and Santa Catarina states, Brazil Ciência Rural
Muller,Gerson Azulim; Dalavequia,Maira Aparecida; Wagner,Glauber; Marcondes,Carlos Brisola.
The study of Diptera of medical importance in areas affected by dam constructions is very important due to the possibility of the occurrence of diseases transmitted by these species. Collections were performed during 2010 and 2011 in an area under impact of a dam on the Uruguai River in the borderland of Rio Grande do Sul and Santa Catarina states. Insects were collected using suction tubes and Shannon trap, also immature live forms were obtained by manual collect. Eight-hundred sixty-one Diptera insects were captured, including Haemagogus leucocelaenus (Culicidae), Aedes albopictus (Culicidae), three species of Anopheles spp. (Culicidae), two of Plebotominae and three distinct Simuliidae species. The Diptera fauna in the area is diversified and species...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Dams; Diptera; Environmental impact; Vectors.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782014000701194
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Controle de tripes que atacam a soja. Infoteca-e
CORSO, I. C.; GAZZONI, D. L..
Estudos com inseticidas granulados sistemicos para controle de tripes; Uso de metodos culturais para o controle da queima do broto.
Tipo: Séries anteriores (INFOTECA-E) Palavras-chave: Inseto vetor; Controle; Brasil; Soybean; Disease; Insect; Vectors; Thrips; Control.; Doença; Tripes; Soja; Vírus.; Brazil..
Ano: 1982 URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/445307
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Detección, disperción y muestreo en la erradicación del Citrus Tristeza Virus en plantaciones comerciales de cítricos Colegio de Postgraduados
Ruiz García, Noé.
La dispersión espacio-temporal del Citrus tristeza virus se caracterizó en Tamaulipas de diciembre de 2001 a marzo de 2004, en 11 huertos comerciales de naranja dulce injerta- dos en naranjo agrio. Adicionalmente, se comparó el desempeño de la técnica serológica inmunoimpresión-ELISA con respecto a DAS-ELISA propuesta en la normatividad ofi- cial mexicana de la Campaña Nacional contra CTV. El objetivo fue proporcionar bases epidemiológicas e incorporar criterios de diagnóstico viral en una propuesta de muestreo con fines de erradicación. Inmunoimpresión-ELISA fue tan confiable (97.8 %) como DAS-ELISA en identificar árboles positivos, siendo 54.9% más económica e implicó solo una sexta parte del tiempo de procesado. La detectabilidad en impresiones...
Tipo: Tesis Palavras-chave: Citrus tristeza virus; Serología; Muestreo; Vectores; Epidemiología Citrus tristeza virus; Serology; Sampling; Vectors; Epidemiology.
Ano: 2012 URL: http://hdl.handle.net/10521/1020
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Detección, dispersión y muestreo en la erradicación del Citrus Tristeza Virus en plantaciones comerciales de cítricos Colegio de Postgraduados
Ruiz García, Noé.
La dispersión espacio-temporal del Citrus tristeza virus se caracterizó en Tamaulipas de diciembre de 2001 a marzo de 2004, en 11 huertos comerciales de naranja dulce injerta- dos en naranjo agrio. Adicionalmente, se comparó el desempeño de la técnica serológica inmunoimpresión-ELISA con respecto a DAS-ELISA propuesta en la normatividad ofi- cial mexicana de la Campaña Nacional contra CTV. El objetivo fue proporcionar bases epidemiológicas e incorporar criterios de diagnóstico viral en una propuesta de muestreo con fines de erradicación. Inmunoimpresión-ELISA fue tan confiable (97.8 %) como DAS-ELISA en identificar árboles positivos, siendo 54.9% más económica e implicó solo una sexta parte del tiempo de procesado. La detectabilidad en impresiones...
Tipo: Tesis Palavras-chave: Citrus tristeza virus; Serología; Muestreo; Vectores; Epidemiología; Doctorado; Fitopatología; Fitopatología; Serology; Sampling; Vectors; Epidemiology.
Ano: 2008 URL: http://hdl.handle.net/10521/1348
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Imaturos de mosquito (Diptera, Culicidae) de áreas urbana e rural no norte do Estado do Paraná, Brasil Iheringia, Sér. Zool.
Silva,Allan Martins da.
The results of larval collections of mosquitoes from artificial containers and natural breeding at urban and rural areas carried out at Sertaneja, northern State Paraná, Brazil, from February to April, 1995, are presented. Among the 4534 immature forms collected, belonging to 21 species or species-groups, the species with higher density were Aedes aegypti (Linnaeus, 1762), Aedes albopictus (Skuse, 1894), Culex quinquefasciatus Say, 1823 and Limatus durhami Theobald, 1901.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Culicidae; Larvae; Vectors; Brazil.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0073-47212002000400005
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Injective mappings and solvable vector fields Anais da ABC (AABC)
Santos Filho,José R. dos; Tavares,Joaquim.
We establish a sufficient condition for injectivity in a class of mappings defined on open connected subsets of Rn , for arbitrary n. The result relates solvability of the appropriate vector fields with injectivity of the mapping and extends a result proved by the first author for n < 3 . Furthermore, we extend the result to connected paracompact smooth oriented manifolds and show that the convexity condition imposes strong topological restrictions on the manifold.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Fields; Injectivity; Mappings; Solvability; Vectors.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652010000300002
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Nyssomyia intermedia (Lutz &amp; Neiva) and Nyssomyia neivai (Pinto) (Diptera, Psychodidae, Phlebotominae) in a sympatric area: seasonal and nocturnal hourly rhythm in black and white modified Shannon traps Rev. Bras. entomol.
Galati,Eunice A. B.; Marassá,Ana Maria; Gonçalves-Andrade,Rute Maria; Bueno,Edna Fátima Maria; Paiva,Byanca R.; Malafronte,Rosely S..
Captures with black and white Shannon traps were undertaken to identify aspects of the behavior of the two cryptic and sympatric species implicated as vectors of cutaneous leishmaniasis, Nyssomyia intermedia (Lutz &amp; Neiva, 1912) and Nyssomyia neivai (Pinto, 1926). The traps were installed side by side, monthly, from July 2001 to June 2002, from 18 to 07 hours, in a peridomicile of Iporanga municipality, state of São Paulo, Brazil. A total of 2,142 specimens were captured, Ny. intermedia (47.4%) and Ny. neivai (50.5%). The white trap was more attractive to both sexes of both species. Males of Ny. neivai predominated (70%) over those of Ny. intermedia on the two traps; on the black trap, the females of Ny. intermedia predominated (63.3%) over those...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ecology; Cutaneous leishmaniasis; Ribeira Valley; Vectors.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0085-56262010000400021
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Phlebotomines (Diptera, Psychodidae) in the Ribeira Valley Speleological Province - 1. Parque Estadual Intervales, state of São Paulo, Brazil Rev. Bras. entomol.
Galati,Eunice Aparecida Bianchi; Marassá,Ana Maria; Gonçalves-Andrade,Rute Maria; Consales,Cleide Aschenbrenner; Bueno,Edna F. M..
The identification of the sandfly fauna and investigation of some ecological aspects of its populations in areas frequented by tourists of the PEI, an Atlantic forest reserve with many caves, were the objective of this study. Captures were undertaken monthly from January 2001 to December 2002, with automatic light traps installed in 13 ecotopes, including caves, forests, domiciliary and peridomiciliary environments, and by aspiration in armadillo burrows. Additionally, although not at regular intervals, Shannon traps were installed in forests and anthropic environments, aspirations were made on cave walls, among roots and fallen leaves, and some insects were captured while biting researchers. A total of 891 sandflies belonging to 21 species were captured....
Tipo: Info:eu-repo/semantics/report Palavras-chave: Atlantic forest; Cave; Leishmaniasis; Vectors.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0085-56262010000200015
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Phlebotomines (Diptera, Psychodidae) in the Speleological Province of the Ribeira Valley: 2. Parque Estadual do Alto Ribeira (PETAR), São Paulo State, Brazil Rev. Bras. entomol.
Galati,Eunice A. B.; Marassá,Ana Maria; Gonçalves-Andrade,Rute Maria; Consales,Cleide Aschenbrenner; Bueno,Edna Fátima Maria.
The Parque Estadual do Alto Ribeira (PETAR) with about 250 caves, in an Atlantic forest reserve, is an important ecotourist attraction in the Ribeira Valley, an endemic area of American cutaneous leishmaniasis (ACL). With the purpose of investigating Leishmania vector species bothersome to humans the sandfly fauna was identified and some of its ecological aspects in the Santana nucleus, captures were undertaken monthly with automatic light traps in 11 ecotopes, including caves, forests, a camping site and domiciliary environments, and on black and white Shannon traps, from January/2001 to December/2002. A total of 2,449 sandflies representing 21 species were captured. The highest values of abundance obtained in the captures with automatic light traps were...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Caves; Ecology; Leishmaniasis; Sandfly; Vectors.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0085-56262010000300020
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Phlebotomines (Diptera, Psychodidae) in the Speleological Province of the Ribeira Valley: 3. Serra district - area of hostels for tourists who visit the Parque Estadual do Alto Ribeira (PETAR), state of São Paulo, Brazil Rev. Bras. entomol.
Galati,Eunice Aparecida Bianchi; Marassá,Ana Maria; Fonseca,Mauro Breviglieri; Gonçalves-Andrade,Rute Maria; Consales,Cleide Aschenbrenner; Bueno,Edna Fátima Maria.
Phlebotomines (Diptera, Psychodidae) in the Speleological Province of the Ribeira Valley: 3. Area of hostels for tourists who visit the Parque Estadual do Alto Ribeira (PETAR), state of São Paulo, Brazil. The study characterizes some ecological aspects of the phlebotomine fauna in an endemic area of cutaneous leishmaniasis (CL) situated in the Serra district, Iporanga municipality where the hostels for tourists visiting the PETAR are located. Captures were undertaken on a smallholding and a small farm situated near the hostels, monthly between January/2001 and December/2003 with automatic light traps (ALT) in pigsty, hen-house and veranda of a domicile at the two sites, and in peridomicile of the small farm also with black/white Shannon traps. With the ALT...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ecology; Leishmaniases; Lutzomyia longipalpis; Phlebotominae; Vectors.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0085-56262010000400020
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Polymorphism, inter-population and inter-specific variation in Nyssomyia intermedia (Lutz &amp; Neiva) and Nyssomyia neivai (Pinto) (Diptera, Psychodidae, Phlebotominae) Rev. Bras. entomol.
Andrade Filho,José Dilermando; Galati,Eunice A. Bianchi; Falcão,Alda Lima.
Nyssomyia intermedia (Lutz &amp; Neiva) and Nyssomyia neivai (Pinto) are morphologically very close and both present great variation in some structures. The objective of this study is a description of the variation among the females of these species in populations from the States of Minas Gerais and São Paulo. The morphological structures studied were the number of horizontal teeth in the cibarium and the number of rings and the shape of the terminal knob of the spermathecae. The spermatheca rings are significantly more numerous in N. intermedia than in N. neivai and the simple shape of the terminal knob predominated in both species. Regarding the cibarium, eight to eleven teeth have been found in both species, with up to twelve teeth in the latter....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sandflies; Leishmaniosis; Vectors.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0085-56262006000300008
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Somatic gene therapy for hypertension BJMBR
Phillips,M.I..
Gene therapy for hypertension is needed for the next generation of antihypertensive drugs. Current drugs, although effective, have poor compliance, are expensive and short-lasting (hours or one day). Gene therapy offers a way to produce long-lasting antihypertensive effects (weeks, months or years). We are currently using two strategies: a) antisense oligodeoxynucleotides (AS-ODN) and b) antisense DNA delivered in viral vectors to inhibit genes associated with vasoconstrictive properties. It is not necessary to know all the genes involved in hypertension, since many years of experience with drugs show which genes need to be controlled. AS-ODN are short, single-stranded DNA that can be injected in naked form or in liposomes. AS-ODN, targeted to angiotensin...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Gene therapy; Hypertension; Antisense; Vectors.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000600013
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The community of Diptera (Insecta) colonizing axils of Alocasia macrorrhizos (L.) G.Don (Araceae), with records of Aedes aegypti (L.) and Aedes albopictus (Skuse) in urban areas of Manaus, Amazonas Biota Neotropica
Ferreira-Keppler,Ruth Leila; Neiss,Ulisses Gaspar; Torreias,Sharlene Roberta da Silva; Campos,Claudimir Menezes.
Abstract Alocasia macrorrhizos (L.) G.Don grows and proliferates in shaded areas in several forest fragments in urban zones. The adult plant has axils that accumulate rain water (phytotelmata) and serve as breeding sites for several families of aquatic insects. The objective of this study was to determine the composition of the entomofauna associated with water accumulations in axils of A. macrorrhizos in urban areas of Manaus, Brazil. Individuals of A. macrorrhizos were sampled in five forest fragments, between April/2005 and March/2007 in urban areas of Manaus, totaling 184 sampling units. A manual suction hose was used for the removal of entomofauna. A total of 1,941 immatures of Diptera were collected representing the following families: Culicidae...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Culicidae; Forest fragments; Mosquitoes; Phytotelmata; Vectors.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-06032017000300201
Registros recuperados: 14
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